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Published on: May 21, 2019
MicroRNA-196b promotes cell proliferation and suppress cell differentiation in vitro
Donglin Cao1, Liangshan Hu1, Da Lei1
1Department of Laboratory Medicine, Guangdong No. 2 Provincial People's Hospital, Guangzhou 510317, PR China.
Abstract:
MicroRNA-196b (miR-196b) is frequently amplified and aberrantly overexpressed in acute leukemias. To investigate the role of miR-196b in acute leukemias, it has been observed that forced expression of this miRNA increases proliferation and inhibits apoptosis in human cell lines. More importantly, we show that this miRNA can significantly increase the colony-forming capacity of mouse normal bone marrow progenitor cells alone, as well as partially blocking the cells from differentiation. Taken together, our studies suggest that miRNA-196b may play an essential role in the development of MLL-associated leukemias through inhibiting cell differentiation and apoptosis, while promoting cell proliferation.
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