Relationship between premature ejaculation and chronic prostatitis/chronic pelvic pain syndrome

Area of Science:

• Urology
• Men's Health
• Sexual Health

Background:

• Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a frequent cause of premature ejaculation (PE).
• Existing data are insufficient to fully explain this association or support routine screening for PE in men with CP/CPPS.

Purpose of the Study:

• To investigate the relationship between premature ejaculation (PE) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Main Methods:

• A cross-sectional study involving 8,261 men utilizing the Premature Ejaculation Diagnostic Tool (PEDT) and NIH-Chronic Prostatitis Symptom Index (NIH-CPSI).
• Assessments included the International Index of Erectile Function-5 (IIEF), metabolic work-up, and testosterone levels.
• Statistical analyses employed Spearman correlation, multiple linear regression, and logistic regression.

Main Results:

• A significant positive correlation was observed between PEDT and NIH-CPSI pain scores (r=0.206, P<0.001), persisting after adjustments.
• The odds ratio for PE increased with pelvic pain severity (mild: 1.269, moderate/severe: 2.134).
• 24.2% of men had PE (PEDT>10) and 24.9% had prostatitis-like symptoms (NIH-CPSI pain score ≥4).

Conclusions:

• A significant correlation exists between premature ejaculation (PE) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
• Routine screening for CP/CPPS in men with PE, and PE in men with CP/CPPS, is suggested.