Haemolytic and co-haemolytic (CAMP-like) activity in dermatophytes

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Aylin Döğen1, Ramazan Gümral, Macit İlkit

  • 1Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Mersin, Mersin, Turkey.

Mycoses
|December 6, 2014
PubMed

Insights

This study investigated dermatophyte haemolytic and CAMP-like activities, finding these factors are common in most strains regardless of origin. These fungal virulence factors were best detected using ovine and bovine red blood cells.

Area of Science:

  • Mycology
  • Medical Mycology
  • Fungal Pathogenesis

Background:

  • Dermatophytes are common fungal pathogens causing infections in humans and animals.
  • Enzymes like keratinases contribute to dermatophyte pathogenesis.
  • Haemolytic and CAMP-like activities in dermatophytes are poorly understood but significant in bacterial pathogenesis.

Purpose of the Study:

  • To characterize haemolytic and CAMP-like activities in various dermatophyte strains.
  • To determine optimal conditions for detecting these activities.
  • To explore potential correlations between these activities and dermatophyte characteristics.

Main Methods:

  • Testing 45 dermatophyte strains from genera Arthroderma, Epidermophyton, Microsporum, and Trichophyton.
  • Utilizing Columbia agar supplemented with bovine, ovine, and equine erythrocytes.
  • Observing haemolysis and CAMP-like reactions over different incubation periods.

Main Results:

  • Haemolysis was most evident on ovine erythrocyte agar, followed by equine and bovine.
  • CAMP-like reactions were observed with bovine and ovine erythrocytes, but not equine.
  • Both activities were detected in most dermatophyte strains, irrespective of lesion type (symptomatic or asymptomatic).

Conclusions:

  • Haemolytic and CAMP-like activities are prevalent among dermatophytes.
  • Ovine and bovine erythrocytes are superior for detecting these activities.
  • These fungal activities do not appear correlated with ecological factors, isolation sites, or clinical presentation.
Keywords:
CAMP factordermatophyteshaemolysinkeratinophilicvirulence

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