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Association of hematocrit and pre-hypertension among Chinese adults: the CRC study

Xuekui Liu1, Jun Liang, Qinqin Qiu

  • 1Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009, Jiangsu, China.

Cell Biochemistry and Biophysics
|December 6, 2014
PubMed

Insights

Higher hematocrit levels are linked to an increased risk of pre-hypertension in Chinese adults. This association was independent of metabolic factors but not significant in individuals over 60.

Area of Science:

  • Cardiovascular Health
  • Metabolic Syndrome
  • Hematology

Background:

  • Elevated blood pressure is a key risk factor for cardiovascular diseases and diabetes.
  • Understanding factors associated with pre-hypertension is crucial for early intervention.

Purpose of the Study:

  • To investigate the relationship between hematocrit and pre-hypertension in Chinese adults.
  • To explore the influence of sex, obesity, glucose, and lipid levels on this association.

Main Methods:

  • Analysis of data from a community-based health examination survey in China.
  • Inclusion of 23,691 participants with normal blood pressure.
  • Statistical analysis using odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for multiple covariates.

Main Results:

  • A significant trend of increasing pre-hypertension odds with higher hematocrit quartiles (P < 0.001).
  • Associations were observed in both men and women, but not in those over 60 years.
  • Low-density lipoprotein cholesterol (LDL-C) showed a significant interaction with hematocrit (P < 0.024), particularly at lower and median levels.

Conclusions:

  • Hematocrit is independently associated with pre-hypertension in Chinese adults, irrespective of common metabolic risk factors.
  • The association is not significant in older adults (over 60).
  • Low-density lipoprotein cholesterol levels may modify the relationship between hematocrit and pre-hypertension.

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