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Updated: Aug 6, 2026

A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening
Published on: October 16, 2015
A label-free fluorescent assay for free chlorine in drinking water based on protein-stabilized gold nanoclusters
Xiaoli Xiong1, Yan Tang1, Liangliang Zhang2
1College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, China.
Abstract:
Bovine serum albumin stabilized Au nanoclusters (BSA-AuNCs) were demonstrated as a novel fluorescence probe for sensitive and selective detection of free chlorine in drinking water. The fluorescence of BSA-AuNCs was found to be quenched effectively by the free chlorine, and the decrease in fluorescence intensity of BSA-AuNCs allowed the sensitive detection of free chlorine in the range of 0.8-800 μM. The detection limit is 0.50 μM at a signal-to-noise ratio of 3. The present fluorescent assay for free chlorine possesses low detection limit, wide linear range and good selectivity. Real tap water samples were analyzed with satisfactory results, which suggested its potential for water quality analysis.
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