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Updated: Apr 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[Classical patterns of interstitial lung diseases]
1Institut für CT und MRT, Umfahrungsstr. Nord 7, 2230, Gänserndorf, Österreich, mueller-mang@ct-mrt.com.
Insights
High-resolution computed tomography (HRCT) identifies four basic interstitial lung disease (ILD) patterns. Radiologists can use these HRCT patterns and clinical data for diagnosis, but collaboration is often needed.
Area of Science:
- Radiology
- Pulmonology
- Medical Imaging
Background:
- High-resolution computed tomography (HRCT) is crucial for diagnosing and monitoring interstitial lung disease (ILD).
- Accurate ILD diagnosis relies on interpreting complex imaging patterns.
Purpose of the Study:
- To systematically review HRCT patterns of ILD.
- To discuss differential diagnoses for ILD based on HRCT findings.
- To provide a diagnostic roadmap for radiologists managing ILD.
Main Methods:
- Systematic review of HRCT patterns in ILD.
- Analysis of pattern localization within the secondary pulmonary lobule (SPL).
- Consideration of lung distribution (e.g., lobe predominance).
Main Results:
- Four basic HRCT patterns of ILD identified: linear/reticular, nodular, high attenuation, and low attenuation.
- Patterns are further classified by SPL localization (centrilobular, perilymphatic) and lung distribution.
- Clinical data (smoking history, disease course) aid diagnosis.
Conclusions:
- HRCT patterns and anatomical distribution aid ILD diagnosis in some cases.
- Morphological and clinical overlap necessitates collaboration between clinicians, radiologists, and pathologists for definitive ILD diagnosis.
Background:
High resolution computed tomography (HRCT) is the most important non-invasive tool in the diagnostics and follow-up of patients with interstitial lung disease (ILD).
Objectives:
A systematic review of the HRCT patterns of ILD was carried out and the most relevant differential diagnoses are discussed in order to provide a road map for the general radiologist to successfully navigate the complex field of ILD.
Results:
Using HRCT four basic patterns of ILD can be identified: linear and reticular patterns, the nodular pattern, the high attenuation and low attenuation patterns. These patterns can be further differentiated according to their localization within the secondary pulmonary lobule (SPL), e.g. centrilobular or perilymphatic and their distribution within the lungs (e.g. upper or lower lobe predominance). Relevant clinical data, such as smoking history and course of the disease provide useful additional information in the diagnosis of ILD.
Conclusion:
On the basis of the pattern and anatomical distribution on HRCT, an accurate diagnosis can be achieved in some cases of ILD; however, due to morphological and clinical overlap the final diagnosis of many ILDs requires close cooperation between clinicians, radiologists and pathologists.
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