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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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MDM2-p53 pathway in hepatocellular carcinoma

Xuan Meng1, Derek A Franklin2, Jiahong Dong3

  • 1Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Hospital and Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China. Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, China.

Cancer Research
|December 6, 2014
PubMed
Summary

Alterations in the TP53 gene and MDM2 overexpression are common in cancers, particularly hepatocellular carcinoma (HCC). Understanding the MDM2-p53 feedback loop offers potential for improved cancer diagnostics, prognostics, and therapeutics.

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