Related Experiment Video
Updated: Apr 19, 2026

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
Published on: June 6, 2025
BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result
E A Howe1, A de Souza2, D L Lahr1
1Center for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
The BioAssay Research Database (BARD) now offers structured access to NIH Molecular Libraries Program bioassay data. It supports data submission, querying, and tool development for chemical biology research.
Area of Science:
- Chemical Biology
- Bioinformatics
- Scientific Databases
Background:
- The NIH Molecular Libraries Program (MLP) generated extensive bioassay data.
- Accessing and utilizing this data required standardized formats and tools.
Purpose of the Study:
- To present BARD, a public database and tool suite for accessing MLP bioassay data.
- To facilitate data submission, querying, and third-party tool development.
Main Methods:
- Migration of data from 631 MLP projects into a structured vocabulary.
- Development of user-friendly tools for data submission and assay definition.
- Implementation of an application program interface (API) for data access.
Main Results:
- BARD provides formalized bioassay data with emphasis on assay protocols.
- Web-based query tools and a desktop client enable data access.
- The API supports the development of integrated or stand-alone research tools.
Conclusions:
- BARD serves researchers, data publishers, and developers in chemical biology.
- The database enhances the utility of curated bioassay data for hypothesis generation.
- BARD promotes collaborative development of chemical biology research tools.
More Related Videos
08:31Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
05:35An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome
Published on: September 20, 2022
Related Concept Videos
DNA Microarrays
Proteomics
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Labeling DNA Probes
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...