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Translational Orthotopic Models of Glioblastoma Multiforme
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Glioblastoma multiforme - an overview.

Kaja Urbańska1, Justyna Sokołowska1, Maciej Szmidt1

  • 1Division of Histology and Embryology, Department of Morphological Science, Faculty of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, Warsaw, Poland.

Contemporary Oncology (Poznan, Poland)
|December 6, 2014
PubMed
Summary
This summary is machine-generated.

Glioblastoma multiforme is a grade IV brain tumor. While primary glioblastomas arise from normal cells, secondary ones develop from lower-grade tumors, with differing genetics but similar morphology.

Keywords:
brainetiologyglioblastoma multiformerisk factorstreatmenttumor

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Area of Science:

  • Neuro-oncology
  • Cancer Biology
  • Genetics

Background:

  • Glioblastoma multiforme (GBM) is a WHO grade IV central nervous system tumor.
  • Over 90% of GBMs are primary, originating from glial cells via multistep oncogenesis.
  • Secondary GBMs, comprising 10%, arise from lower-grade tumors and grow slower.

Purpose of the Study:

  • To summarize current knowledge on glioblastoma multiforme development.
  • To review glioblastoma multiforme treatment modalities and influencing factors.
  • To highlight gaps in comprehensive brain tumor analysis.

Main Methods:

  • Literature review of glioblastoma multiforme pathogenesis.
  • Analysis of genetic alterations and molecular pathway deregulation in GBM.
  • Compilation of data on glioblastoma multiforme treatment strategies.

Main Results:

  • GBM exhibits distinct genetic pathways for primary and secondary forms, yet similar morphology.
  • Cell cycle deregulation (G1/S checkpoint) and genetic abnormalities drive GBM progression.
  • Treatment effectiveness and prognosis are influenced by tumor characteristics and patient factors.

Conclusions:

  • Despite recent research, comprehensive analysis of glioblastoma multiforme development and treatment remains insufficient.
  • Understanding the diverse origins and progression pathways is crucial for targeted therapies.
  • Multifaceted treatment approaches considering tumor biology and patient status are essential for managing GBM.