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Thymic carcinoma presenting as disseminated intravascular coagulation
Mamatha Siricilla1, Jawairia Memon1, Robert Avery1
1University of Alabama Birmingham Montgomery Internal Medicine, Montgomery, AL 36116, USA.
Case Reports in Oncological Medicine
|December 6, 2014
Summary
We report a rare thymic carcinoma case initially presenting with disseminated intravascular coagulation (DIC). Corticosteroid therapy improved DIC, and the thymic carcinoma responded well to chemoradiation.
Area of Science:
- Oncology
- Pathology
Background:
- Thymomas and thymic carcinomas are rare neoplasms originating from thymic epithelial cells.
- Disseminated intravascular coagulation (DIC) is a rare but serious complication of various malignancies.
Purpose of the Study:
- To present a unique case of thymic carcinoma with initial presentation of DIC.
- To highlight the management and treatment response in this rare clinical scenario.
Main Methods:
- Case report detailing clinical presentation, diagnostic workup, and treatment of thymic carcinoma.
- Review of relevant literature on thymic malignancies and DIC.
Main Results:
- The patient's thymic carcinoma initially manifested as DIC.
- DIC symptoms significantly improved following corticosteroid administration.
- The thymic carcinoma demonstrated a positive response to chemoradiation therapy.
Conclusions:
- Thymic carcinoma can present with DIC as an initial paraneoplastic manifestation.
- Corticosteroids may be effective in managing DIC associated with thymic carcinoma.
- Chemoradiation is a viable treatment option for thymic carcinoma.
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