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Vitamin d levels in children with bronchial asthma

A R Somashekar1, Ashwini B Prithvi2, M N Vanitha Gowda3

  • 1Professor, Department of Paediatrics, M S Ramaiah Medical College and Hospitals , Bangalore, India .

Journal of Clinical and Diagnostic Research : JCDR
|December 6, 2014
PubMed

Insights

Vitamin-D deficiency is common in children with asthma and is linked to reduced lung function. Lower serum vitamin-D levels in asthmatic children correlate with airway limitation, suggesting a potential role for vitamin D in managing childhood asthma.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Nutritional Science

Background:

  • Bronchial asthma is a prevalent chronic airway inflammatory condition in children.
  • Vitamin D, essential for bone health, also modulates the immune system and may influence allergic diseases.
  • Understanding vitamin D's role in pediatric asthma is crucial for potential therapeutic strategies.

Purpose of the Study:

  • To compare serum vitamin D levels between children with asthma and healthy controls.
  • To investigate the association between vitamin D levels and asthma severity in children.
  • To explore the correlation between vitamin D status and lung function parameters in asthmatic children.

Main Methods:

  • A cross-sectional study involving 88 children (44 asthmatic, 44 healthy) aged 5–13 years.
  • Measurement of serum 25-hydroxy vitamin D levels for all participants.
  • Analysis of lung function parameters (FEV1%, FEV1/FVC%) in the asthmatic cohort.

Main Results:

  • Asthmatic children exhibited significantly lower serum vitamin D levels compared to healthy controls.
  • A significant positive correlation was observed between vitamin D levels and FEV1% in asthmatic children.
  • Vitamin D levels also showed a significant positive correlation with the FEV1/FVC% ratio in the asthmatic group.

Conclusions:

  • Vitamin D deficiency is highly prevalent among children diagnosed with asthma.
  • Lower vitamin D levels in asthmatic children are associated with measurable airway limitation.
  • These findings highlight the potential clinical significance of vitamin D status in pediatric asthma management.
Abstract

Keywords:
Airway limitationAsthmaChildrenLung functionVitamin-D

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