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Related Concept Videos

Hepatitis01:25

Hepatitis

66
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Hepatitis C: liver transplantation.

Julius Metts1, Lesley Carmichael2, Winfred Kokor3

  • 1California Substance Abuse and Treatment Center, 900 Quebec Ave, Corcoran, CA 93212.

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Hepatitis C virus (HCV) is a leading cause of liver transplants in the US. Post-transplant care involves managing complications like infection, rejection, and long-term health issues related to immunosuppression.

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Area of Science:

  • Hepatology
  • Transplant Surgery
  • Immunology

Background:

  • Hepatitis C virus (HCV)-related cirrhosis and hepatocellular carcinoma are primary indications for adult liver transplantation in the US, accounting for 40% of procedures.
  • Liver transplant survival rates range from 76-83% at 2 years and 69-72% at 5 years.

Purpose of the Study:

  • To outline the criteria and considerations for liver transplantation in HCV-infected patients.
  • To detail common complications and long-term health issues following liver transplantation.
  • To define the role of family physicians in managing post-transplant recipients.

Main Methods:

  • Review of current practices and outcomes for liver transplantation in HCV patients.
  • Identification of eligibility criteria, including substance abuse history and MELD score.
  • Analysis of post-transplant complications and associated medical conditions.

Main Results:

  • HCV patients with decompensated liver disease or hepatocellular carcinoma are candidates if eligible for surgery.
  • Abstinence from substance abuse for at least 6 months is typically required.
  • Common complications include HCV recurrence, organ rejection, infections, diabetes, hypertension, hyperlipidemia, renal dysfunction, osteopenia, and secondary cancers.

Conclusions:

  • Liver transplantation is a viable option for select HCV patients, but requires careful management of post-operative complications.
  • Long-term health issues, often linked to immunosuppressive therapy, necessitate vigilant monitoring by healthcare providers.
  • Family physicians play a crucial role in the ongoing care and management of liver transplant recipients.