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[3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients
J Kornhuber1, F Mack-Burkhardt, P Riederer
1Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
Journal of Neural Transmission
|January 1, 1989
Abstract:
[3H]MK-801 binding was used as a marker for the NMDA receptorion channel complex in postmortem brain samples from the frontal cortex, hippocampus, putamen, entorhinal region, and amygdala of schizophrenic patients and controls. In schizophrenia [3H]MK-801 binding levels were increased in all brain regions investigated reaching significance in the putamen.