Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone induction in a composite allogeneic bone/alloplastic implant.

U Ripamonti1, C M Schnitzler, P C Cleaton-Jones

  • 1MRC/University of the Witewaterstand, Dental Research Institute, Johannesburg, South Africa.

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
|September 1, 1989
PubMed
Summary

Autolyzed antigen-extracted allogeneic (AAA) bone shows morphogenetic properties for bone regeneration. However, combining AAA bone with porous hydroxyapatite biomatrix (HAB) inhibited bone formation in rat models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinal vascular occlusion in pregnancy: three case reports and a review of the literature.

Journal of medical case reports·2022
Same author

[Immunological tolerance of intraocular eyelashes after penetrating corneal injury].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2019
Same author

A mass guide for the harvest of cortico-cancellous bone from the posterior iliac crest for mandibular reconstruction.

The British journal of oral & maxillofacial surgery·2019
Same author

New technique for endoscopically-assisted particulate graft reconstruction of the mandible.

The British journal of oral & maxillofacial surgery·2018
Same author

Tissue segregation restores the induction of bone formation by the mammalian transforming growth factor-β(3) in calvarial defects of the non-human primate Papio ursinus.

Biomaterials·2016
Same author

Redefining the induction of periodontal tissue regeneration in primates by the osteogenic proteins of the transforming growth factor-β supergene family.

Journal of periodontal research·2016

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Research

Background:

  • The bone matrix's potential as a biological delivery system for bone regeneration is under investigation.
  • Allogeneic bone grafts are used in bone repair, but their integration with synthetic materials needs further study.

Purpose of the Study:

  • To evaluate the morphogenetic properties of autolyzed antigen-extracted allogeneic (AAA) bone as a delivery system.
  • To assess the effect of combining AAA bone with porous hydroxyapatite biomatrix (HAB) in extraskeletal implants.

Main Methods:

  • Seventy-two allogeneic diaphyseal bone cylinders were processed into AAA bone.
  • Composite implants of AAA bone and HAB were created and implanted in rats.
  • Histological analysis was performed at multiple time points (23-63 days).

Related Experiment Videos

Main Results:

  • AAA bone alone induced endochondral bone differentiation in 84% of implants.
  • Composite AAA bone/HAB implants showed limited bone induction (26%), with macrophage and giant cell infiltration.
  • Bone formation was inhibited within the porous HAB and delayed in composite implants.

Conclusions:

  • AAA bone possesses inherent bone-inductive properties.
  • Porous hydroxyapatite biomatrix appears to inhibit or delay bone formation when combined with AAA bone.
  • Further research is needed to optimize composite biomaterials for bone regeneration.