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Prospects of molecularly-targeted therapies for cervical cancer treatment

Antonio Carlos de Freitas, Maria da Conceição Gomes Leitão, Eliane Campos Coimbra1

  • 1Laboratory of Molecular Studies and Experimental Therapy Studies, Department of Genetics, Federal University of Pernambuco, Cidade Universitária, CEP 50.670-901, Recife - Pernambuco, Brazil. acf_ufpe@yahoo.com.br.

Current Drug Targets
|December 6, 2014
PubMed

Insights

Cervical cancer, a leading cause of death for women globally, is linked to persistent high-risk human papillomavirus (HPV) infections. This review explores molecular targeted therapies for HPV-related cervical dysplasia and carcinoma, addressing an urgent need for effective treatments.

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Cervical cancer is a major global health concern, particularly in developing nations, causing significant mortality.
  • Persistent high-risk human papillomavirus (HPV) oncoproteins (E5, E6, E7) disrupt the cell cycle and gene expression, contributing to cervical cancer development.
  • Current therapies are insufficient, as they do not directly target HPV infection, highlighting the need for novel treatment strategies.

Purpose of the Study:

  • To review current molecular targeted therapies for HPV-related cervical dysplasia and carcinoma.
  • To highlight potential therapeutic strategies that may impact the treatment of cervical cancer.
  • To address the urgent need for effective cervical cancer treatments, especially in resource-limited settings.

Main Methods:

  • Literature review of molecular targeted therapies for cervical cancer.
  • Analysis of the role of HPV oncoproteins in cervical carcinogenesis.
  • Examination of emerging therapeutic approaches targeting HPV-related pathways.

Main Results:

  • The review identifies several molecular targeted therapies under investigation for cervical cancer.
  • These therapies aim to counteract the effects of HPV oncoproteins and restore normal cellular function.
  • The potential impact of these therapies on treating cervical dysplasia and carcinoma is discussed.

Conclusions:

  • Molecular targeted therapies show promise for the treatment of HPV-related cervical cancer.
  • Further research and clinical trials are necessary to validate these approaches.
  • Effective treatments are crucial, particularly for high-burden regions globally.

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