Related Experiment Video
Updated: Apr 19, 2026
14:48
Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
Published on: March 21, 2021
5.7K
Serum inflammatory factor and cytokines in AECOPD
Tie-Gang Jia1, Jian-Qing Zhao1, Jian-Hua Liu1
1Department of Respiratory Medicine, First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075061, China.
Asian Pacific Journal of Tropical Medicine
|December 7, 2014
Summary
Serum levels of Interleukin-32 (IL-32) and Matrix Metalloproteinase-9 (MMP-9) are elevated in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and correlate negatively with lung function.
Area of Science:
- Pulmonary Medicine
- Immunology
- Biomarker Research
Background:
- Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a significant clinical event.
- Understanding the underlying inflammatory and proteolytic processes in AECOPD is crucial for effective management.
Purpose of the Study:
- To investigate the serum levels of Interleukin-32 (IL-32), Matrix Metalloproteinase-9 (MMP-9), Procalcitonin (PCT), and C-reactive protein (CRP) in patients experiencing AECOPD.
- To compare these biomarker levels between AECOPD patients and those with acute asthma attacks.
Main Methods:
- Serum samples were collected from 50 AECOPD patients and 45 acute asthma patients.
- Levels of IL-32, MMP-9, PCT, and CRP were quantified using Double antibody sandwich Enzyme linked immunosorbent assay, immunofluorescence double antibody sandwich assay, and immunoturbidimetry assay.
- Statistical comparisons were performed between the two patient groups.
Main Results:
- Serum concentrations of IL-32, MMP-9, PCT, and CRP were significantly higher in the AECOPD group compared to the acute asthma group (P<0.05).
- IL-32 and MMP-9 showed a negative correlation with lung function parameters.
- MMP-9 levels were notably increased in AECOPD patients.
Conclusions:
- Elevated serum IL-32 and MMP-9 levels are associated with AECOPD.
- These biomarkers demonstrate a negative correlation with lung function, indicating that poorer lung function is linked to higher levels of IL-32 and MMP-9.
- MMP-9 may serve as a particularly sensitive indicator of disease severity in AECOPD.
More Related Videos
Related Concept Videos
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
21
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
21
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.3K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.3K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.4K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.4K
01:19Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations
20
Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet...
20
01:25Acute Inflammation II: Local and Systemic Effects
6
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
6
01:20COPD: Pathogenesis and Clinical Features
2.3K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.3K