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Updated: Apr 19, 2026

Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica
Published on: October 28, 2022
Guidelines for the diagnosis and monitoring of silicosis
Ramón Fernández Álvarez1, Cristina Martínez González1, Aida Quero Martínez1
1Área de Gestión de Pulmón, Servicio de Neumología, Hospital Universitario Central de Asturias, Oviedo, España.
Abstract:
Silicosis is one of the occupational respiratory diseases most commonly encountered in our setting. It is caused by inhalation of crystalline silica that triggers a fibrotic response in the lung parenchyma. It presents as diffuse interstitial disease and clinical expression ranges from asymptomatic forms to chronic respiratory failure. Diagnosis is based on clinical history and radiological findings. There is no effective treatment, and once diagnosed, the patient must avoid all sources of occupational exposure. In these guidelines, the clinical, radiological and functional aspects of silicosis are reviewed, and strategies for diagnosis, monitoring and classification of patients are proposed, along with recommendations regarding the occupational implications of this disease.
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