Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

6.3K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
6.3K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

7.6K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.6K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

4.4K
4.4K
Metastasis02:30

Metastasis

7.0K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
7.0K
The Tumor Microenvironment02:17

The Tumor Microenvironment

8.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.3K
The Tumor Microenvironment02:17

The Tumor Microenvironment

3.2K
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IL-2 mutein promotes antigen-specific transplant acceptance in mice through expansion of ST2<sup>+</sup> regulatory T cells.

Nature communications·2026
Same author

Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma.

Mucosal immunology·2026
Same author

Conserved CD8 T cell vaccines without B cell epitopes drive robust protection against SARS-CoV-2 that is enhanced by intranasal boost.

Science advances·2025
Same author

Guidelines for T cell nomenclature.

Nature reviews. Immunology·2025
Same author

Viral Infection and the Blood-Brain Barrier: Molecular Research Insights and Therapies.

The Journal of infectious diseases·2025
Same author

Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Apr 19, 2026

In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

142.2K

Chemokines in cancer.

Melvyn T Chow1, Andrew D Luster2

  • 1Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Cancer Immunology Research
|December 7, 2014
PubMed
Summary

Chemokines, signaling proteins, regulate immune cell movement and directly impact tumor growth and metastasis. Understanding the chemokine system offers new avenues for enhancing cancer immunotherapy.

More Related Videos

In Vitro Assay to Study Tumor-macrophage Interaction
08:36

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

8.2K
Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
09:44

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

8.9K

Related Experiment Videos

Last Updated: Apr 19, 2026

In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

142.2K
In Vitro Assay to Study Tumor-macrophage Interaction
08:36

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

8.2K
Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
09:44

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

8.9K

Area of Science:

  • Immunology
  • Cancer Biology
  • Molecular Biology

Background:

  • Chemokines are signaling proteins that control cell migration and tissue positioning.
  • The chemokine system comprises ligands and G protein-coupled receptors, influencing immune cell trafficking into tumors.
  • Chemokines play dual roles, with both anti-tumor and pro-tumor activities mediated by diverse leukocyte subsets.

Purpose of the Study:

  • To review recent advances in understanding the chemokine system's role in tumor biology.
  • To explore how the chemokine system can be leveraged to improve cancer immunotherapeutic strategies.
  • To focus on eliciting more robust and long-lasting host anti-tumor immune responses.

Main Methods:

  • Literature review of recent advances in chemokine research related to cancer.
  • Analysis of the dual roles of chemokines in tumor microenvironment.
  • Focus on the application of chemokine system knowledge in cancer immunotherapy.

Main Results:

  • Chemokines directly influence cancer cell proliferation, apoptosis, and metastasis.
  • Chemokines modulate tumor growth indirectly via stromal cells and growth factor release.
  • The chemokine system's complexity presents opportunities for therapeutic augmentation.

Conclusions:

  • Chemokines are critical regulators of tumor growth, progression, and metastasis.
  • Targeting the chemokine system can enhance the efficacy of cancer immunotherapies.
  • Further research into the chemokine system is vital for developing effective cancer treatments.