Related Experiment Videos
High-resolution footprints of the DNA-binding domain of Epstein-Barr virus nuclear antigen 1
A S Kimball1, G Milman, T D Tullius
1Department of Biology, McCollum-Pratt Institute, Baltimore, Maryland.
Molecular and Cellular Biology
|June 1, 1989
Abstract:
The DNA-binding domain of Epstein-Barr virus nuclear antigen 1 was found by hydroxyl radical footprinting to protect backbone positions on one side of its DNA-binding site. The guanines contacted in the major groove by the DNA-binding domain of Epstein-Barr virus nuclear antigen 1 were identified by methylation protection. No difference was found in the interaction of the DNA-binding domain of Epstein-Barr virus nuclear antigen 1 with tandemly repeated and overlapping binding sites.