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Related Experiment Video

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In Silico Clinical Trials for Cardiovascular Disease
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ICMA: an integrated cardiac modeling and analysis platform.

Jagir R Hussan1, Peter J Hunter1, Patrick A Gladding1

  • 1Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, Waitemata District Health Board, North Shore Hospital, Auckland 0622, New Zealand, National Space Biomedical Research Institute, Houston, TX 77030-1402, USA, Cleveland Clinic Foundation, Cleveland, OH 44195, USA and Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Bioinformatics (Oxford, England)
|December 7, 2014
PubMed
Summary

The open-source ICMA software framework enables 3D finite element modeling of the left ventricle from cardiac imaging data. It facilitates strain analysis using standard methods and a web interface.

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Area of Science:

  • Cardiovascular Imaging and Modeling
  • Medical Software Development

Background:

  • Accurate 3D modeling of the left ventricle is crucial for understanding cardiac function.
  • Existing tools may have hardware limitations or lack comprehensive analysis capabilities.

Purpose of the Study:

  • To introduce ICMA, an open-source software framework for creating 3D finite element models of the left ventricle.
  • To enable hardware-independent analysis of cardiac ultrasound and MRI data.

Main Methods:

  • Utilizes speckle tracking and endocardial border detection on DICOM images.
  • Implements methods in C++ using open-source tools, wrapped as web services.
  • Orchestrates processes via a JBoss-based application server.

Main Results:

  • Provides a hardware vendor-independent framework for 3D left ventricle modeling.
  • Enables standard American Heart Association segment-based strain analysis through a browser interface.
  • The software is available as open-source code.

Conclusions:

  • ICMA offers a flexible and accessible solution for advanced cardiac modeling and analysis.
  • The open-source nature promotes wider adoption and potential for community-driven improvements.