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Comparison between adults and children with Henoch-Schönlein purpura nephritis

Shan Lu1, Dong Liu, Jing Xiao

  • 1Department of Nephrology, First Affiliated Hospital of Zhengzhou University, No.1, JianShe East Road, Zhengzhou, Henan Province, The People's Republic of China.

Pediatric Nephrology (Berlin, Germany)
|December 8, 2014
PubMed

Insights

Age impacts Henoch-Schönlein purpura nephritis (HSPN) outcomes. Adults and children show distinct clinical and pathological features, with severe pathology linked to proteinuria, renal failure, and pain. Renal biopsy is crucial for both groups.

Area of Science:

  • Nephrology
  • Pediatric Nephrology
  • Rheumatology

Background:

  • Henoch-Schönlein purpura (HSP) predominantly affects children, but age is a key prognostic factor.
  • Kidney involvement in HSP significantly contributes to patient mortality.
  • Understanding clinicopathological differences between pediatric and adult HSP is crucial.

Purpose of the Study:

  • To investigate the clinicopathological correlations in adult versus pediatric patients with Henoch-Schönlein purpura nephritis (HSPN).

Main Methods:

  • Retrospective evaluation of 208 children and 75 adult patients diagnosed with HSPN.
  • All participants underwent renal biopsy for detailed pathological assessment.

Main Results:

  • Pediatric patients exhibited higher rates of extra-renal symptoms (arthritis, abdominal pain) compared to adults.
  • Adult patients showed a higher incidence of renal symptoms like edema and hypertension.
  • Pathological findings correlated significantly with clinical presentation, with activity linked to renal failure and chronicity associated with age and proteinuria.

Conclusions:

  • Significant clinicopathological disparities exist between pediatric and adult HSPN patients.
  • Severe HSPN pathology is associated with massive proteinuria, renal failure, and abdominal pain.
  • Renal biopsy is recommended for both pediatric and adult HSPN patients presenting with recurrent hematuria or persistent proteinuria.
Abstract

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