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Updated: Apr 19, 2026

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Published on: January 19, 2024
The tight junction protein JAM-A functions as coreceptor for rotavirus entry into MA104 cells
Jesús M Torres-Flores1, Daniela Silva-Ayala1, Marco A Espinoza1
1Instituto de Biotecnología, Universidad Nacional Autónoma de México. Avenida Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos 62210, México.
Abstract:
Several molecules have been identified as receptors or coreceptors for rotavirus infection, including glycans, integrins, and hsc70. In this work we report that the tight junction proteins JAM-A, occludin, and ZO-1 play an important role during rotavirus entry into MA104 cells. JAM-A was found to function as coreceptor for rotavirus strains RRV, Wa, and UK, but not for rotavirus YM. Reassortant viruses derived from rotaviruses RRV and YM showed that the virus spike protein VP4 determines the use of JAM-A as coreceptor.
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