Related Experiment Video

Updated: Apr 19, 2026

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.6K

PLC and PI3K/Akt/mTOR signalling in disease and cancer

Matilde Y Follo1, Lucia Manzoli1, Alessandro Poli1

  • 1Department of Biomedical and Neuromotor Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy.

Advances in Biological Regulation
|December 9, 2014
PubMed

Insights

Cancer cell metabolism involves deregulated signaling pathways like Phospholipase C (PLC) and PI3K/Akt/mTOR. These pathways are crucial for cell growth and are altered in cancer, impacting apoptosis and proliferation.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cancer cell metabolism is frequently deregulated.
  • Signaling pathways, including PI3K/Akt/mTOR and Phospholipase C (PLC), are implicated in normal cell growth and cancer pathophysiology.
  • Alterations in these pathways contribute to uncontrolled proliferation and evasion of apoptosis in cancer cells.

Purpose of the Study:

  • To review the critical roles of Phospholipase C (PLC) and PI3K/Akt/mTOR signaling pathways in cancer pathophysiology.
  • To highlight how these pathways are exploited by cancer cells.
  • To provide an overview of the involvement of these signaling cascades in neoplastic transformation.

Main Methods:

  • Literature review of scientific articles and research papers.
  • Analysis of the involvement of PLC and PI3K/Akt/mTOR pathways in cancer.
  • Synthesis of current knowledge on the pathophysiology of these signaling pathways in cancer.

Main Results:

  • The PI3K/Akt/mTOR pathway is essential for normal proliferation and differentiation but is altered in cancer, aiding survival.
  • Phospholipase C (PLC) enzymes are vital for cell growth, and their dysregulation is linked to cancer development.
  • Both pathways interact and are exploited by cancer cells to promote growth and resist apoptosis.

Conclusions:

  • Dysregulation of PLC and PI3K/Akt/mTOR signaling pathways is a common feature in cancer.
  • Targeting these pathways presents potential therapeutic strategies for cancer treatment.
  • Understanding these signaling mechanisms is crucial for advancing cancer research and therapy.
Keywords:
NucleusPI3K/Akt/mTORPhospholipase C

More Related Videos

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

957
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

18.9K

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
6.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.8K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
8.0K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
14.2K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
19.7K