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Serotonin syndrome in stroke patients
Sung Ho Jang1, Yong Min Kwon, Min Cheol Chang
1Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University , Seoul, Republic of Korea.
Stroke patients may develop serotonin syndrome from dopaminergic agents. Early recognition and drug discontinuation led to full recovery in two reported cases, highlighting the need for clinical vigilance.
Area of Science:
- Neurology
- Pharmacology
- Clinical Medicine
Background:
- Serotonin syndrome is a serious condition caused by increased serotonergic activity.
- Dopaminergic agents are frequently used in stroke rehabilitation.
- Communication deficits in stroke patients can mask early symptoms.
Observation:
- Two stroke patients developed serotonin syndrome after receiving ropinirole or carbidopa/levodopa.
- Symptoms emerged with increased drug dosage and resolved after discontinuation.
Findings:
- Both patients met revised Radomski's criteria for serotonin syndrome.
- Complete recovery was observed within two days of stopping the offending medications.
Implications:
- Clinicians must be vigilant for serotonin syndrome in stroke patients prescribed dopaminergic agents.
- Communication barriers in stroke patients may complicate early diagnosis.
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