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Acid-sensing ion channels: trafficking and pathophysiology
Wei-Zheng Zeng1, Di-Shi Liu, Tian-Le Xu
1a Discipline of Neuroscience and Department of Anatomy; Histology and Embryology; Institute of Medical Sciences ; Shanghai Jiao Tong University School of Medicine ; Shanghai 200025 , P.R. China.
Channels (Austin, Tex.)
|December 9, 2014
Summary
Acid-sensing ion channels (ASICs) are crucial in the nervous system and disease. This review explores ASIC trafficking, focusing on membrane insertion and endocytosis, to understand their role in health and disease.
Area of Science:
- Neuroscience
- Molecular Biology
- Channelopathies
Background:
- Acid-sensing ion channels (ASICs) are proton-gated cation channels vital in the peripheral and central nervous systems.
- ASICs are implicated in pathophysiological conditions linked to tissue acidosis, including stroke, seizures, and multiple sclerosis.
Purpose of the Study:
- To review recent advances in understanding ASIC trafficking.
- To discuss the contribution of ASIC trafficking to ASIC function and pathophysiological roles.
Main Methods:
- Literature review of recent research on ASIC trafficking mechanisms.
- Focus on membrane insertion and endocytosis of ASIC1a.
Main Results:
- ASIC trafficking, particularly membrane insertion and endocytosis of ASIC1a, is increasingly recognized for its role in regulating ASIC function.
- Recent findings highlight the significance of trafficking in ASIC's contribution to neurological disorders.
Conclusions:
- ASIC trafficking is a critical, yet understudied, area in understanding ASIC channel function.
- Further research into ASIC trafficking mechanisms is essential for developing therapeutic strategies for ASIC-related diseases.
Keywords:
accessory proteinsacid-sensing ion channelsmotifssignaling pathwayssurface expressiontrafficking
