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Persistent viral DNA synthesis associated with an avian osteopetrosis-inducing virus
R E Aurigemma1, R D Comstock, R E Smith
1Department of Microbiology, Colorado State University, Ft. Collins 80523.
Virology
|August 1, 1989
Abstract:
Bone and red blood cell DNA was obtained from MAV-2(O) infected, osteopetrotic chickens and analyzed for the presence of integrated and unintegrated viral DNA. Results indicate that unintegrated MAV-2(O) DNA did not appear until after osteopetrotic lesions were well established. These observations lead us to conclude that, unlike some retroviral diseases, unintegrated viral DNA may not play a significant role in the pathogenesis of MAV-2(O) osteopetrosis. In addition, there was no evidence of a clonally derived tumor in the bone.