Coaxial electrohydrodynamic atomization: microparticles for drug delivery applications.

Area of Science:

• Biomedical Engineering
• Materials Science
• Oncology

Background:

• Conventional cancer therapies like chemotherapy and radiotherapy present challenges including adverse side effects and poor patient compliance.
• Tumor physiopathology significantly impacts the efficacy of cancer treatment strategies.
• There is a need for advanced drug delivery systems (DDS) for controlled and sustained therapeutic agent administration.

Purpose of the Study:

• To provide an overview of double-walled microparticles for local cancer drug delivery.
• To focus on the electrohydrodynamic atomization (EHDA) technique for fabricating these microparticles.
• To discuss the challenges associated with EHDA fabrication and the importance of integrated design approaches.

Main Methods:

• Review of existing literature on double-walled microparticles for drug delivery.
• Focus on the electrohydrodynamic atomization (EHDA) technique for microparticle fabrication.
• Emphasis on the synergy between experimental validation and computational simulations for system design.

Main Results:

• Double-walled microparticles show promise for localized and sustained drug release in cancer therapy.
• Electrohydrodynamic atomization (EHDA) is a key technique for fabricating these advanced DDS.
• Optimization of DDS requires a combined approach of experimental data and computational modeling.

Conclusions:

• Double-walled microparticles represent a significant advancement in local drug delivery for cancer treatment.
• The electrohydrodynamic atomization (EHDA) technique, despite fabrication challenges, is crucial for developing these systems.
• Integrating experimental and simulation data is essential for designing effective and optimized drug delivery systems.