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Meningitis caused by Neisseria Meningitidis, Hemophilus Influenzae Type B and Streptococcus Pneumoniae during

Mehmet Ceyhan1, Nezahat Gürler, Yasemin Ozsurekci

  • 1a Department of Pediatric Infectious Diseases ; Hacettepe University Faculty of Medicine ; Ankara , Turkey.

Human Vaccines & Immunotherapeutics
|December 9, 2014
PubMed

Insights

Bacterial meningitis etiology in Turkish children was determined using multiplex PCR. Neisseria meningitidis, Streptococcus pneumoniae, and Hib were identified, highlighting the need for broad meningococcal vaccines.

Area of Science:

  • Pediatric Infectious Diseases
  • Microbiology
  • Vaccinology

Background:

  • Bacterial meningitis prevention relies on understanding causative agents.
  • Etiological determination is crucial for effective vaccination strategies.

Purpose of the Study:

  • To determine the bacterial etiology of meningitis in children in Turkey.
  • To inform vaccination policies by identifying prevalent bacterial pathogens.

Main Methods:

  • Prospective collection of cerebrospinal fluid (CSF) samples from hospitalized children (1 month to 18 years).
  • Multiplex polymerase chain reaction (PCR) used to detect DNA of Neisseria meningitidis, Streptococcus pneumoniae, and Hemophilus influenzae type b (Hib).

Main Results:

  • Bacterial etiology was identified in 44.4% of 1452 CSF samples.
  • Neisseria meningitidis was the most frequent isolate (51.6%), followed by Streptococcus pneumoniae (30.2%) and Hib (18.1%).
  • Among N. meningitidis isolates, serogroup W-135 was most common (38.1%), followed by serogroup B (26.1%).

Conclusions:

  • Available vaccines target the most frequent bacterial isolates identified.
  • Results underscore the necessity for comprehensive meningococcal disease protection in Turkey.
Keywords:
HibMeningitisN. meningitidisS. pneumoniaeTurkeyepidemiologyetiologic agentssurveillance

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