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Measles virus

Hussein Y Naim1

  • 1a Life Sciences and Vaccines Consultant; Bern, Switzerland.

Human Vaccines & Immunotherapeutics
|December 9, 2014
PubMed

Insights

Measles virus (MV) vaccines have reduced severe illness but not eradicated the disease. Novel molecular techniques now enable MV

Area of Science:

  • Virology
  • Immunology
  • Vaccinology

Background:

  • Measles virus (MV) historically caused significant morbidity and mortality.
  • Live attenuated MV vaccines reduced disease severity but failed to eradicate measles.
  • Continued measles outbreaks highlight the need for improved control strategies.

Purpose of the Study:

  • To review the advancements in measles virus (MV) research enabled by molecular biology.
  • To explore the potential of MV as a vector for novel vaccines and therapeutics.
  • To discuss the future prospects of MV-based recombinant strategies.

Main Methods:

  • Review of literature on MV biology, pathogenesis, and vaccine development.
  • Analysis of molecular techniques, including cDNA rescue of MV.
  • Evaluation of recombinant MV vector applications.

Main Results:

  • Molecular biology techniques have provided deep insights into MV biology and pathogenesis.
  • Novel vaccine candidates inducing immunity against measles and other pathogens have been developed.
  • MV shows promise as a platform for recombinant vaccines and therapeutic vectors.

Conclusions:

  • Despite vaccination, measles remains a global health concern.
  • Molecular advancements have opened new avenues for measles control.
  • Recombinant MV holds significant potential for future vaccine and therapeutic applications.
Keywords:
SSPElive viral vaccinemeaslespathogenesisrecombinant vaccinesvaccineviral vectors

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