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A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
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Tecemotide: an antigen-specific cancer immunotherapy
Gregory T Wurz1, Chiao-Jung Kao, Michael Wolf
1a University of California , Davis; Department of Internal Medicine; Division of Hematology and Oncology ; Sacramento , CA USA.
Human Vaccines & Immunotherapeutics
|December 9, 2014
Summary
Tecemotide targets tumor-associated Mucin 1 (MUC1) for cancer immunotherapy. Preclinical studies in MUC1 mouse models aim to optimize MUC1-targeted therapy timing with chemoradiotherapy for improved patient outcomes.
Area of Science:
- Oncology
- Immunology
- Biochemistry
Background:
- Tumor-associated antigens (TAA) enable targeted cancer immunotherapies.
- Mucin 1 (MUC1) is a tumor-associated antigen overexpressed and aberrantly glycosylated in cancer.
- Tecemotide is an immunotherapy designed to target MUC1.
Purpose of the Study:
- To review the preclinical and clinical development of tecemotide.
- To discuss ongoing preclinical studies of tecemotide in MUC1 transgenic mouse models.
- To explore optimizing the timing of tecemotide immunotherapy with chemoradiotherapy.
Main Methods:
- Review of preclinical and clinical data for tecemotide.
- Preclinical studies utilizing human MUC1 transgenic mouse models of breast and lung cancer.
- Evaluation of combination therapy timing strategies.
Main Results:
- Tecemotide is in Phase III trials for non-small cell lung cancer (NSCLC) maintenance therapy.
- Phase II studies are exploring tecemotide in other cancer indications.
- Preclinical models are being used to investigate optimal treatment sequencing.
Conclusions:
- Tecemotide shows promise as an MUC1-targeted cancer immunotherapy.
- MUC1 transgenic mouse models offer a platform for optimizing combination therapies.
- Further research aims to improve treatment outcomes for NSCLC and other cancers.
Keywords:
ADT, androgen deprivation therapyAPC, antigen presenting cellASI, active specific immunotherapyBSC, best supportive careCEA, carcinoembryonic antigenCI, confidence intervalCONSORT, consolidated standards of reporting trialsCPA, cyclophosphamideCRT, chemoradiotherapyCTL, Cytotoxic T-lymphocyteChemoradiotherapyDMPG, Dimyristoyl phosphatidylglycerolDPPC, Dipalmitoyl phosphatidylcholineDTH, delayed-type hypersensitivityECOG, Eastern cooperative oncology groupELISpot, enzyme-linked immunosorbent spotFACT-L, functional assessment of cancer therapy-lungGy, grayHLA, human lymphocyte antigenHR, hazard ratioIFN-γ, interferon gammaIL-2, Interleukin 2INSPIRE, stimuvax trial in Asian NSCLC patients: stimulating immune responseITT, intent to treatIgG, immunoglobulin GKLH, keyhole limpet hemocyaninLICC, L-BLP25 in colorectal cancerLR, locoregionalMAP, multiple antigenic peptideMHC, major histocompatibility complexMMT, muc1-expressing mammary tumorMPLA, monophosphoryl lipid AMUC1MUC1, Mucin 1MUC1.Tg, MUC1 transgenicNSCLC, non-small cell lung cancerOH-BBN, N-butyl-N-(4-hydroxybutyl)nitrosamineOS, overall survivalPBL, peripheral blood lymphocytesPCR, pathological complete remissionPSA, prostate specific antigenPyV-mT, polyomavirus middle-TQOL, quality of lifeRCB, residual cancer burdenRECIST, response evaluation criteria in solid tumorsRTX, radiotherapySTART, stimulating targeted antigenic responses to NSCLCTAA, tumor associated antigenTGF-β, transforming growth factor βTH1, T-helper type ITH2, T-helper type IITNF-α, tumor necrosis factor αTOI, trial outcome indexVNTR, variable number of tandem repeatsi.v., intravenousimmunotherapynon-small cell lung cancertecemotideMore Related Videos
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