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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
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Application of current diagnostic criteria for arrhythmogenic right ventricular cardiomyopathy in every day clinical

Eleanor C Wicks, Perry M Elliott1

  • 1The Heart Hospital, 16-18 Westmoreland Street, London, W1G 8PH. eleanor.wicks@nhs.net.

Current Pharmaceutical Design
|December 9, 2014
PubMed

Insights

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart condition causing sudden death. This review examines revised diagnostic criteria for ARVC, highlighting the need for ongoing improvements in accuracy.

Area of Science:

  • Cardiology
  • Genetics
  • Pathology

Background:

  • Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disease linked to sudden cardiac death, ventricular arrhythmias, and heart failure.
  • It primarily affects the desmosome, with mutations in desmosomal protein genes found in about 50% of patients, leading to fibrofatty replacement of cardiomyocytes and ventricular dilation.

Purpose of the Study:

  • To review the application of revised clinical diagnostic criteria for ARVC in practice.
  • To highlight the necessity for continued refinement of these criteria to enhance their diagnostic sensitivity and specificity.

Main Methods:

  • Review of current literature and clinical practice guidelines regarding ARVC diagnosis.
  • Analysis of the revised diagnostic criteria, considering pathology, genetics, and clinical presentation.

Main Results:

  • The revised criteria provide a framework for ARVC diagnosis, integrating multiple factors.
  • Application in practice reveals areas where sensitivity and specificity can be further improved.

Conclusions:

  • The current revised criteria for diagnosing arrhythmogenic right ventricular cardiomyopathy are a significant step forward.
  • Continuous modification and validation are essential to optimize the diagnostic accuracy for this inherited cardiac condition.

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