[Experimental investigation of self-soluble cava-filter]

Area of Science:

• Biomaterials Science
• Vascular Surgery
• Medical Device Innovation

Background:

• Pulmonary embolism (PE) is a significant cause of sudden death, affecting one-third of patients.
• Endovascular interventions, such as inferior vena cava (IVC) filter implantation, offer promise for PE prevention and treatment of IVC thrombosis.

Purpose of the Study:

• To create a self-soluble cava-filter for preventing pulmonary embolism.
• To evaluate the feasibility of one-stage implantation and the absorption characteristics of the developed filter.

Main Methods:

• Experiments were conducted using 18 rabbits as animal models.
• Copolymer rods were implanted to assess dissolution and biocompatibility in the vena cava and surrounding tissues.
• The extent of cava-filter absorption and any toxic effects were evaluated.

Main Results:

• Implanted copolymer rods demonstrated complete dissolution within 40-50 days in muscle and ear veins.
• The developed cava-filter showed partial dissolution.
• No adverse effects on animal health or signs of toxicity were observed.

Conclusions:

• The study suggests the potential of soluble copolymer for cava-filter development.
• Further research is warranted to optimize the design and ensure complete dissolution of the cava-filter for clinical application.