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Updated: Apr 19, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
Delivering value in dermatology: insights from skin cancer detection in routine clinical visits
Monica Enamandram1, Lyn M Duncan2, Alexandra B Kimball1
1Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Background:
There are increasing demands to demonstrate and report on outcomes in dermatology. Skin cancer diagnosis through skin examination has been well studied, and is promising as a value-delivering intervention.
Objective:
This study seeks to identify the rate of skin cancer diagnosis during routine visits to a large tertiary dermatology clinic.
Methods:
Medical records of patients presenting for routine dermatologic care at Massachusetts General Hospital between March 28 and September 28, 2012, were retrospectively reviewed. All patients given a diagnosis of nonmelanoma skin cancer (NMSC) confirmed on biopsy specimen were identified. Billing data were used to identify the total number of patients evaluated during the study period.
Results:
NMSC was diagnosed in 1266 skin biopsy specimens from 1047 (7.0%) of the 14,829 patients who presented for routine care. In all, 55% of patients with NMSC were men (mean age 70 years). Chief symptoms of patients with NMSC included general dermatologic concerns (37%), routine cancer screening (43%), and specific lesion(s) of concern (19%).
Limitations:
Retrospective design and restriction to a single institution may limit the generalizability of our findings.
Conclusion:
The incidence of NMSC in routine dermatology is high; these findings validate the value of care provided by dermatologists and highlight the likely increasing need for their diagnostic skills as the population ages in the United States.
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