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Published on: March 10, 2017
Hepcidin expression in psoriasis patients
Nursel Dilek1, Aziz Ramazan Dilek2, Kazim Sahin2
1Department of Dermatology, Recep Tayyip Erdoğan University, Medical Faculty Hospital, Rize, Turkey.
Background:
Iron is an essential nutrient for mammals. Accelerated loss of nutrients through hyperproliferation and desquamation from the skin in psoriasis is known. Hepcidin is an important and recently discovered regulator of iron homeostasis.
Aims And Objectives:
The present study was undertaken to investigate the hepcidin expression in psoriasis patients.
Materials And Methods:
We examined peripheral blood cell counts, serum Fe, ferritin, interleukin-6 (IL-6) and hepcidin levels using respectively automated hematology analyzer, Iron assay on the AEROSET system, chemiluminescent microparticle immunoassay with automated analyzer, and enzyme-linked immunosorbent assay.
Results:
The independent comparison of Fe, ferritin, IL-6 and hepcidin levels in psoriasis patients and control group (healthy volunteers) revealed lower Fe and higher IL-6, hepcidin levels in psoriasis patients. No significant difference was seen in the ferritin level between the psoriasis and the control group.
Conclusions:
We think that studies on hepcidin expression in psoriatic plaques will contribute to our understanding the role of iron and hepcidin in the pathogenesis of psoriasis.
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