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Updated: Apr 19, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
A familial poikiloderma-like cutaneous amyloidosis
Mahesh Unni1, Balachandra Ankad1, Varna Naidu1
1Department of Dermatology, S. Nijlingappa Medical College, Bagalkot, Karnataka, India.
Abstract:
Familial poikiloderma-like cutaneous amyloidosis(FPLCA) is a rare, generalized but genetic dyschromic skin disorder characterized by amyloid deposits in dermis due to defective DNA repair secondary to sunlight damage. Clinically, it presents with diffuse brownish pigmentation with hypo-pigmented macules and many brownish scattered lichenoid papules with normal developmental milestones. The condition is autosomal dominant with incomplete penetrance. We are here reporting a rare familial case of FPLCA with a review of the literature.
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