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Fixed drug eruption due to ornidazole
1Department of Dermatology, Indraprastha Apollo Hospital Sarita Vihar, New Delhi, India.
Indian Journal of Dermatology
|December 9, 2014
Summary
Fixed drug eruption is a rare adverse reaction to medications. A case study identified ornidazole as the cause of fixed drug eruption in a patient presenting with genital and lip ulcers after taking multiple antibiotics.
Area of Science:
- Dermatology
- Pharmacology
- Internal Medicine
Background:
- Fixed drug eruption (FDE) is an uncommon adverse drug reaction.
- It characteristically recurs at the same site(s) with re-exposure to the offending drug.
- Genital and mucosal involvement can occur in FDE.
Purpose of the Study:
- To report a case of fixed drug eruption.
- To identify the specific causative agent among multiple co-administered antibiotics.
- To highlight the diagnostic utility of oral provocation testing in FDE.
Main Methods:
- A 56-year-old male presented with genital and lip ulcers.
- Clinical diagnosis of FDE was considered.
- An oral provocation test was performed using ofloxacin, cephalexin, and ornidazole sequentially.
Main Results:
- The patient developed recurrent lesions on his glans penis and lips.
- Lesions reappeared exclusively upon administration of ornidazole.
- Ofloxacin and cephalexin did not trigger any reaction.
Conclusions:
- Ornidazole was confirmed as the causative agent for fixed drug eruption in this patient.
- Oral provocation testing is a reliable method for identifying the culprit drug in FDE.
- Awareness of FDE is crucial for clinicians managing patients on multiple medications.
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