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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Dermatofibrosarcoma protuberans at an uncommon site.

Vidyadhar R Sardesai1, Rohan M Patil1, Trupti D Agarwal1

  • 1Department of Dermatology, Venereology and Leprosy, Bharati Vidyapeeth University Medical College and Hospital, Pune, India.

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|December 9, 2014
PubMed
Summary

Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer. This case highlights a DFSP diagnosis in a 40-year-old male, confirmed by CD 34 marker, treated with surgical resection.

Keywords:
CD34dermatofibrosarcoma protuberanssoft tissue sarcoma

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Area of Science:

  • Oncology
  • Dermatology
  • Surgical Pathology

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive skin cancer.
  • DFSP typically presents on the trunk and extremities in adults aged 6-65.
  • Diagnosis is aided by immunohistochemical markers, notably CD 34.

Purpose of the Study:

  • To report a case of DFSP occurring in the pubic region.
  • To emphasize diagnostic features and treatment of this rare cutaneous malignancy.

Main Methods:

  • Clinical presentation of a 40-year-old male with a pubic mass.
  • Histopathological examination of biopsy tissue.
  • Immunohistochemical staining for human progenitor cell antigen CD 34.

Main Results:

  • Biopsy confirmed DFSP with characteristic spindle-shaped cells in the dermis.
  • CD 34 marker was positive, supporting the diagnosis.
  • The patient underwent wide local surgical resection for tumor removal.

Conclusions:

  • DFSP can occur in unusual locations, such as the pubic area.
  • CD 34 positivity is crucial for DFSP diagnosis.
  • Wide local excision is a primary treatment modality for DFSP.