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Related Experiment Video

Updated: Apr 19, 2026

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

Current concepts in C3 glomerulopathy.

S Thomas¹, D Ranganathan¹, L Francis²

¹Department of Renal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.

Indian Journal of Nephrology

|December 9, 2014

Summary

This summary is machine-generated.

Complement component 3 glomerulopathy (C3G) is a kidney disease characterized by isolated C3 deposits. This review covers C3G pathophysiology, diagnosis, and treatment strategies for this rare condition.

Keywords:

Alternate complement pathway complement component 3 glomerulonephritis complement component 3 glomerulopathy complements dense deposit disease

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Area of Science:

Nephrology
Immunology
Pathology

Background:

Complement component 3 glomerulopathy (C3G) is a distinct kidney disease entity.
It includes dense deposit disease and C3 glomerulonephritis.
Histologically, C3G shows isolated C3 deposits without immunoglobulins.

Purpose of the Study:

To review the pathophysiology of C3G.
To outline the clinical features of C3G.
To discuss diagnostic and treatment strategies for C3G.

Main Methods:

Literature review of C3G.
Analysis of pathophysiology.
Summary of clinical presentations.
Evaluation of diagnostic criteria.
Review of therapeutic approaches.

Main Results:

C3G arises from dysregulation of the alternate complement pathway.
Genetic defects and autoantibodies are implicated in C3G.
C3G can mimic common glomerulonephritides.
Understanding pathophysiology aids diagnosis and treatment.

Conclusions:

C3G is a distinct entity within glomerulonephritis.
Dysregulated complement activation is central to C3G.
Comprehensive review provides insights into management.