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Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
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Current concepts in C3 glomerulopathy

S Thomas1, D Ranganathan1, L Francis2

  • 1Department of Renal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.

Indian Journal of Nephrology
|December 9, 2014
PubMed

Insights

Complement component 3 glomerulopathy (C3G) is a kidney disease characterized by isolated C3 deposits. This review covers C3G pathophysiology, diagnosis, and treatment strategies for this rare condition.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Complement component 3 glomerulopathy (C3G) is a distinct kidney disease entity.
  • It includes dense deposit disease and C3 glomerulonephritis.
  • Histologically, C3G shows isolated C3 deposits without immunoglobulins.

Purpose of the Study:

  • To review the pathophysiology of C3G.
  • To outline the clinical features of C3G.
  • To discuss diagnostic and treatment strategies for C3G.

Main Methods:

  • Literature review of C3G.
  • Analysis of pathophysiology.
  • Summary of clinical presentations.
  • Evaluation of diagnostic criteria.
  • Review of therapeutic approaches.

Main Results:

  • C3G arises from dysregulation of the alternate complement pathway.
  • Genetic defects and autoantibodies are implicated in C3G.
  • C3G can mimic common glomerulonephritides.
  • Understanding pathophysiology aids diagnosis and treatment.

Conclusions:

  • C3G is a distinct entity within glomerulonephritis.
  • Dysregulated complement activation is central to C3G.
  • Comprehensive review provides insights into management.

Keywords:
Alternate complement pathwaycomplement component 3 glomerulonephritiscomplement component 3 glomerulopathycomplementsdense deposit disease

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