Periostin induces pancreatic regeneration
Johnathan K Smid1, Sharlene Faulkes, Michael A Rudnicki
1Sprott Center for Stem Cell Research (J.K.S., S.F., M.A.R.), Ottawa Hospital Research Institute, Regenerative Medicine Program, and University of Ottawa (J.K.S., M.A.R.), Cellular and Molecular Medicine, Faculty of Medicine, Ottawa, Ontario, Canada K1H 8L6.
Endocrinology
|December 9, 2014
Summary
The secreted protein periostin (Postn) promotes pancreatic regeneration and improves glucose regulation. Postn deficiency impairs beta-cell regeneration, while Postn administration enhances islet formation and function.
Area of Science:
- Endocrinology
- Regenerative Medicine
- Molecular Biology
Background:
- Partial pancreatectomy triggers tissue regeneration.
- The role of specific secreted proteins in pancreatic regeneration is not fully understood.
Purpose of the Study:
- To investigate the role of periostin (Postn) in pancreatic regeneration after injury.
- To explore the therapeutic potential of Postn for enhancing beta-cell function and glucose homeostasis.
Main Methods:
- Utilized partial pancreatectomy models in Postn-deficient and wild-type mice.
- Administered Postn directly into the pancreas and intraperitoneally.
- Assessed pancreatic regeneration, beta-cell mass, and glucose tolerance.
Main Results:
- Postn deficiency impaired mesenchymal formation and beta-cell regeneration post-pancreatectomy.
- Postn administration stimulated progenitor cell proliferation and mesenchymal stroma formation.
- Direct and systemic Postn delivery increased islet numbers and improved glucose tolerance without adverse effects.
Conclusions:
- Periostin (Postn) is a key mediator of pancreatic regeneration.
- Postn administration shows therapeutic potential for treating diabetes by promoting beta-cell regeneration and improving glucose control.
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