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ISWI chromatin remodeling complexes in the DNA damage response
Özge Z Aydin1, Wim Vermeulen, Hannes Lans
1a Department of Genetics ; Cancer Genomics Netherlands; Erasmus MC ; Rotterdam , The Netherlands.
Cell Cycle (Georgetown, Tex.)
|December 9, 2014
Summary
Chromatin remodeling complexes, specifically the ISWI family, are crucial for the DNA damage response (DDR). These complexes regulate DNA repair pathways, ensuring genomic integrity after DNA damage.
Area of Science:
- Molecular Biology
- Genetics
- Cell Biology
Background:
- DNA damage response (DDR) relies on regulating chromatin structure.
- Chromatin modification and remodeling are vital for DNA repair and signaling.
- ATP-dependent chromatin remodeling complexes play key roles in DDR.
Purpose of the Study:
- To review the role of the mammalian ISWI family in DNA repair pathways.
- To discuss how ISWI complexes regulate DNA repair and are recruited to damaged DNA.
Main Methods:
- Literature review of ISWI complexes in DNA repair.
- Analysis of ISWI involvement in homologous recombination, non-homologous end-joining, and nucleotide excision repair.
Main Results:
- ISWI complexes are implicated in at least three major DNA repair pathways.
- ISWI family members are significant regulators within the DDR.
- ISWI complexes facilitate DNA access and control repair protein activity.
Conclusions:
- The ISWI family is a major player in the mammalian DNA damage response.
- Understanding ISWI complex function is key to comprehending DNA repair mechanisms.
Keywords:
ACF1ACF1, ATP-utilizing Chromatin assembly and remodeling Factor 1ATP-dependent chromatin remodelingBER, Base Excision RepairDDR, DNA Damage ResponseDNA damage responseDSB, Double Strand BreakGG-NER, Global Genome Nucleotide Excision RepairHR, Homologous RecombinationHomologous RecombinationISWIISWI, Imitation SWItchMRN, MRE11/Rad50/NBS1NER, Nucleotide Excision RepairNHEJ, Non-Homologous End JoiningNon-Homologous End-JoiningNucleotide Excision RepairPAR, Poly(ADP-Ribose)RNApolII, RNA Polymerase IIRSF1, Remodeling and Spacing Factor 1SMARCA, SWI-SNF-related Matrix-associated Actin-dependent Regulator of Chromatin ASMARCA5/SNF2HTC-NER, Transcription-Coupled Nucleotide Excision RepairWSTFWSTF, Williams Syndrome Transcription Factor
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