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Updated: Apr 19, 2026

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
Published on: March 15, 2019
[Cardiorespiratory responses of healthy person to increased normobaric inhalation hypoxia]
Abstract:
On almost healthy young men the changes of cardiorespiratory indexes are explored at prolonged (25 mines) exponenticaly dropping concentration of O2 in an inhalation respiratory admixture from 20.9% to 10%. It is shown that the most prompt (during 2-5 mines) is ventilatory equivalent of O2 that testifies to slope of efficacy of interlinking of oxygen in lungs grows. Individual expression of this depression is rather variable (on 22-84% from a reference value) also is substantially caused by the current alveolar ventilation spotting the basic reserve of enriching ventiljatorno-perfuzionnyh of relations in lungs. The subsequent propagation reaction of the cardiac contraction rate meeting in 100% of surveys, is impeded concerning the beginning of a hypoxia and combined with increase of the anoxemia noted on depression of a saturation of haemoglobin of blood O2. The individual gain of the cardiac contraction rate on a hypoxia compounds 8-43% from a datum level and is significantly bound to current diastolic arterial pressure of a blood. Hypoxycal ventilatory response is expressed only in 71% of cases, from which in 15%--is reversed at concomitant depression of a respiration rate.
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