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Semen quality in men with chronic kidney disease and its correlation with chronic kidney disease stages

M Lehtihet1, B Hylander2

  • 1Department of Medicine, Karolinska Institute and Centre for Andrology and Sexual Medicine, Karolinska University Hospital, Huddinge, Sweden.

Andrologia
|December 10, 2014
PubMed

Insights

Chronic kidney disease (CKD) negatively impacts male semen quality, affecting volume, motility, and sperm count. Higher CKD stages correlate with poorer semen parameters, independent of age and BMI.

Area of Science:

  • Nephrology
  • Andrology
  • Reproductive Medicine

Background:

  • Chronic kidney disease (CKD) affects multiple organ systems.
  • The impact of CKD on male reproductive health, specifically semen quality, requires further investigation.

Purpose of the Study:

  • To evaluate the association between different stages of chronic kidney disease (CKD) and semen quality parameters in adult men.
  • To determine the independent effects of CKD stage, age, and body mass index (BMI) on male fertility markers.

Main Methods:

  • Cross-sectional study involving 66 men aged 18-50 with CKD stages 1-5.
  • Analysis of semen parameters including volume, sperm concentration, motility, morphology, and accessory gland markers.
  • Statistical assessment of correlations between CKD stage, age, BMI, and semen quality outcomes.

Main Results:

  • Higher CKD stages showed significant negative trends in semen volume, progressive and nonprogressive motility, sperm concentration, total sperm number, and accessory gland markers (α-glucosidase, zinc, fructose).
  • Body mass index (BMI) did not significantly affect most semen parameters but correlated negatively with sex-hormone-binding globulin (SHBG).
  • Age was associated with decreased sperm concentration, normal morphology, and testosterone levels.

Conclusions:

  • CKD stage is a significant independent factor influencing sperm availability for ejaculation.
  • The detrimental effects of CKD on semen quality are partly independent of age-related hormonal changes and BMI.

Keywords:
Chronic kidney diseasesemen qualitysubfertility

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