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Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
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Polycystic ovaries and obesity.
Ioannis E Messinis1, Christina I Messini1, George Anifandis2
1Obstetrics and Gynaecology, Department of Obstetrics and Gynaecology, University of Thessaly, School of Health Sciences, Faculty of Medicine, 41110 Larissa, Greece.
Best Practice & Research. Clinical Obstetrics & Gynaecology
|December 10, 2014
Summary
Obesity impacts polycystic ovary syndrome (PCOS) and infertility. Lifestyle changes are key for obese women with PCOS seeking conception, while anti-obesity medications and surgery need more research.
Area of Science:
- Reproductive Endocrinology
- Metabolic Disorders
- Gynecology
Background:
- Polycystic Ovary Syndrome (PCOS) frequently coexists with obesity, affecting nearly 50% of affected women.
- Obesity exacerbates PCOS pathophysiology through mechanisms including hyperandrogenism, elevated luteinizing hormone (LH), and insulin resistance.
- Adipose tissue-derived substances like leptin, adiponectin, resistin, and visfatin are implicated in PCOS development.
Purpose of the Study:
- To review the impact of obesity on PCOS and its reproductive consequences.
- To outline current and potential treatment strategies for infertility in obese women with PCOS.
- To discuss the role of weight management in improving fertility outcomes for PCOS patients.
Main Methods:
- Literature review of studies investigating obesity, PCOS, and reproductive health.
- Analysis of the mechanisms linking obesity to hyperandrogenism, anovulation, and insulin resistance in PCOS.
- Evaluation of current and emerging therapeutic interventions for PCOS-related infertility.
Main Results:
- Obesity significantly complicates infertility management in PCOS, primarily due to anovulation.
- First-line ovulation induction includes clomiphene citrate, followed by human gonadotropins.
- Other treatments include metformin, aromatase inhibitors, laparoscopic ovarian drilling, and in vitro fertilization as a last resort.
Conclusions:
- Lifestyle modifications (diet, exercise) are crucial for obese women with PCOS before conception attempts.
- The efficacy of anti-obesity drugs and bariatric surgery in managing PCOS and improving fertility requires further investigation.
- Addressing obesity is essential for optimizing reproductive outcomes in women with PCOS.
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