Related Experiment Video

Updated: Apr 19, 2026

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
08:02

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

Published on: October 19, 2013

19.2K

Pulmonary hypertension in giant omphalocele infants

Emily A Partridge1, Brian D Hanna2, Howard B Panitch3

  • 1Department of Surgery, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, United States.

Journal of Pediatric Surgery
|December 10, 2014
PubMed

Insights

Pulmonary hypertension (PH) affects 37% of giant omphalocele (GO) survivors, increasing mortality and hospital stay. Early detection and management of PH are crucial for improving outcomes in GO patients.

Area of Science:

  • Neonatalogy
  • Pediatric Surgery
  • Pulmonology

Background:

  • Pulmonary hypoplasia is a known complication of giant omphalocele (GO).
  • Pulmonary hypertension (PH) in GO has not been extensively studied.
  • This study investigates PH rates and severity in GO survivors.

Purpose of the Study:

  • To determine the incidence and severity of PH in giant omphalocele survivors.
  • To identify factors associated with PH in GO.
  • To evaluate the impact of PH on clinical outcomes in GO patients.

Main Methods:

  • Retrospective chart review of GO patients in a pulmonary hypoplasia program.
  • Statistical analysis using Fisher's exact test and Mann-Whitney test.
  • Standardized prenatal and postnatal care protocols were followed.

Main Results:

  • PH was diagnosed in 37% of 54 GO patients.
  • PH was associated with longer hospital stays, mechanical ventilation, and tracheostomy.
  • Prenatal imaging of stomach herniation predicted PH with 52% accuracy.
  • Mortality was significantly higher in GO patients with PH (p=0.0460).

Conclusions:

  • Pulmonary hypertension is a significant complication in 37% of giant omphalocele cases.
  • PH management is critical for improving outcomes in GO patients.
  • Prenatal imaging may aid in early PH identification.
Abstract

Keywords:
Abdominal wall defectsPulmonary hypertensionPulmonary hypoplasiaReactive airway disease

More Related Videos

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

14.7K
Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs05:40

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs

Published on: December 22, 2023

672

Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
906
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
5.1K
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
1.4K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
5.3K
Pneumothorax II: Pathophysiology01:08

Pneumothorax II: Pathophysiology

Pneumothorax means the presence of air in the pleural space — the thin potential gap between the visceral and parietal pleura. This condition disrupts the normal pressure balance that keeps the lungs inflated, leading to partial or complete collapse of the affected lung.Normal physiologyUnder normal conditions, the pleural space maintains a slightly negative intrapleural pressure, which keeps the lungs expanded against the chest wall. This negative pressure creates a delicate balance...
21
Pulmonary Edema II: Pathophysiology01:18

Pulmonary Edema II: Pathophysiology

Pulmonary edema is the accumulation of fluid in the interstitial and alveolar spaces of the lungs, impairing gas exchange and oxygen delivery. It may be cardiogenic or noncardiogenic, but both reduce oxygenation and lung compliance.Cardiogenic Pulmonary EdemaCardiogenic edema results from increased hydrostatic pressure in pulmonary capillaries, usually due to left ventricular dysfunction from myocardial infarction, heart failure, or valvular disease. Ineffective cardiac pumping causes blood to...
16