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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

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Reversible dilated cardiomyopathy associated with amphotericin B therapy.

J R Soares¹, M C P Nunes, A F Leite

¹Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Journal of Clinical Pharmacy and Therapeutics

|December 10, 2014

Summary

Amphotericin B can cause reversible dilated cardiomyopathy, a rare side effect. This case highlights potential cardiotoxicity in patients without predisposing factors, warranting further investigation.

Keywords:

amphotericin B cardiomyopathy cardiotoxicity

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Area of Science:

Cardiology
Infectious Diseases
Pharmacology

Background:

Amphotericin B (AmB) is a critical antifungal and antileishmanial agent.
Its clinical utility is often limited by significant adverse effects.
Reversible dilated cardiomyopathy is a rare but documented complication of AmB therapy.

Observation:

A case of acute dilated cardiomyopathy developed in a previously healthy 45-year-old man during AmB treatment for visceral leishmaniasis.
The patient had no predisposing factors for heart failure, differentiating this case from previous reports.
Cardiac function normalized post-treatment, consistent with reversible cardiotoxicity.

Findings:

This report presents the first instance of AmB-induced dilated cardiomyopathy in a patient lacking known cardiac risk factors.
The findings suggest AmB may possess direct cardiotoxic potential.
The cardiotoxicity appears to be reversible upon discontinuation of the drug.

Implications:

Clinicians should consider AmB-induced cardiotoxicity in patients presenting with unexplained heart failure, even without risk factors.
Further research is necessary to elucidate the mechanisms of AmB-induced cardiotoxicity.
This case underscores the importance of vigilant cardiac monitoring during AmB therapy.