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[Immortal time bias in pharmacoepidemiological studies: definition, solutions and examples]

Jean-Luc Faillie1, Samy Suissa2

  • 1Département de pharmacologie médicale et toxicologie, CHRU de Montpellier, Montpellier, France - Service de pharmacologie médicale et clinique, Equipe de recherche de pharmacoépidémiologie, INSERM UMR 1027, CHU de Toulouse, Faculté de médecine Université Paul Sabatier, Toulouse, France.

Therapie
|December 10, 2014
PubMed
Summary

Immortal time bias in drug studies often leads to incorrect conclusions about drug benefits. This bias, stemming from exposure definition issues, can exaggerate or falsely create positive drug effects in observational research.

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