Obesity itself does not influence BDNF serum levels in adults

Area of Science:

• Biochemistry
• Human Physiology
• Metabolic Health

Background:

• Over 50% of European adults are overweight or obese, with significant prevalence in Poland.
• Obesity is a risk factor for type 2 diabetes, hypertension, and metabolic syndrome.
• Brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) are implicated in obesity-related health issues.

Purpose of the Study:

• To investigate the impact of obesity on serum levels of BDNF and IL-6.
• To explore the relationship between these biomarkers and obesity-related comorbidities.
• To assess the influence of age and physical activity on these associations.

Main Methods:

• Study included 144 participants (80 obese, 64 normal weight) aged 45-86.
• Serum levels of BDNF and IL-6 were measured.
• Tests included glucose, lipid profiles (cholesterol, HDL, LDL, triglycerides), and assessment of physical activity.

Main Results:

• Obese women aged ≤65 showed significantly higher IL-6 levels compared to normal-weight women.
• No statistically significant differences in BDNF levels were observed across groups based on sex, age, obesity, or physical activity.
• No significant differences in hypertension, heart failure, or diabetes mellitus were detected between obese and normal-weight participants.

Conclusions:

• Interleukin-6 levels correlate with total cholesterol and triglyceride levels in younger individuals.
• Obesity in women under 65 is associated with elevated IL-6.
• BDNF serum concentration is not significantly influenced by obesity or physical activity in the studied population.