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Inhibitors of Bacterial DNA Synthesis01:28

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Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These...
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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Related Experiment Video

Updated: Apr 19, 2026

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research
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Fluoroquinolone-induced Achilles tendinitis.

P K Tam1, Carmen T K Ho1

  • 1Department of Medicine, Tung Wah Hospital, 12 Po Yan Street, Sheung Wan, Hong Kong.

Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi
|December 10, 2014
PubMed
Summary

Ciprofloxacin, an antibiotic, can cause Achilles tendinitis, a rare side effect. Early suspicion and drug cessation are crucial for managing this fluoroquinolone-induced tendinopathy.

Area of Science:

  • Pharmacology
  • Orthopedics
  • Infectious Diseases

Background:

  • Fluoroquinolones are broad-spectrum antibiotics used for various infections.
  • Tendinopathy, particularly affecting the Achilles tendon, is an emerging adverse effect associated with fluoroquinolone use.

Observation:

  • A case of Achilles tendinitis developed following ciprofloxacin treatment for a respiratory tract infection.

Findings:

  • Fluoroquinolone-induced tendinopathy is an uncommon but recognized adverse effect.
  • The Achilles tendon is the most commonly affected site, with a risk of rupture.
  • Predisposing factors include steroid use, renal impairment, advanced age, and athletic activity.

Implications:

  • Discontinuation of the causative fluoroquinolone is recommended upon suspicion of tendinopathy.
Keywords:
Achilles tendonFluoroquinolones

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  • Symptomatic treatment is advised, with orthopedic consultation indicated for suspected tendon rupture.