Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Valves01:16

Heart Valves

16.9K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
16.9K
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

562
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
562
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

490
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
490
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

631
Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
631
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

1.3K
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Murine Abdominal Aortic Aneurysm Intraluminal Thrombus Composition and Structure.

Annals of biomedical engineering·2026
Same author

Sex- and stressor-dependent effects of metformin on cardiac fibrosis in plasminogen activator inhibitor-1 deficiency.

Journal of molecular and cellular cardiology·2026
Same author

Simplified and Refined Murine Model of Reversible Aortic Constriction for Characterizing Cardiac Functional Recovery.

JACC. Basic to translational science·2026
Same author

Noninvasive surrogate of main pulmonary artery stiffness is associated with right ventricular function in experimental pulmonary arterial hypertension.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Molecular and cellular adaptations to extended hypothermic oxygenated perfusion in donation-after-circulatory-death hearts in a porcine model.

Frontiers in cardiovascular medicine·2026
Same author

Integrated Strain-Flow Analysis for Early Assessment of Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.

Annals of biomedical engineering·2026

Related Experiment Video

Updated: Apr 19, 2026

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

14.3K

Emerging trends in heart valve engineering: Part I. Solutions for future.

Arash Kheradvar1, Elliott M Groves, Lakshmi P Dasi

  • 1Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2410 Engineering Hall, Irvine, CA, 92697-2730, USA, arashkh@uci.edu.

Annals of Biomedical Engineering
|December 10, 2014
PubMed
Summary

This review covers new heart valve replacement research, including tissue-engineered valves and permanent polymeric options. Understanding cellular responses is key for future regenerative therapies.

More Related Videos

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets
10:29

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets

Published on: March 23, 2022

5.1K
A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

6.3K

Related Experiment Videos

Last Updated: Apr 19, 2026

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

14.3K
Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets
10:29

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets

Published on: March 23, 2022

5.1K
A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

6.3K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cardiovascular Engineering

Background:

  • Current heart valve replacement options have limitations.
  • Novel materials and techniques are needed for improved patient outcomes.

Purpose of the Study:

  • To provide an overview of novel heart valve replacement research.
  • To discuss tissue-engineered and polymeric heart valves.
  • To highlight the importance of cellular microenvironment sensing in tissue engineering.

Main Methods:

  • Review of current research and development in heart valve fabrication.
  • Discussion of in vitro and in vivo tissue-engineered heart valves.
  • Analysis of polymeric materials for permanent heart valve prostheses.

Main Results:

  • Polymeric heart valves offer cost-effective, manufacturable, and integrable solutions for adults.
  • Tissue-engineered heart valves represent a promising regenerative, patient-specific future.
  • Cellular response to microenvironmental stimuli is critical for tissue-engineered valve development.

Conclusions:

  • Novel heart valve replacements are advancing beyond current standards.
  • Both polymeric and tissue-engineered approaches present distinct advantages.
  • Further research into cellular mechanisms is essential for optimizing regenerative valve therapies.